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Officers were called at around 2am on Tuesday (29 December) over concerns for a woman with a head injury in Chapel Street.
Emergency services attended the scene and the woman in her 50s was taken to hospital, but sadly she died on Wednesday (30 December).
On Thursday (31 December), a man in his 40s was arrested on suspicion of murder in connection to the incident.
He was released under investigation as detectives continue their enquiries.
A post-mortem examination was carried out on Saturday (2 January) and determined the woman’s cause of death as a head injury. The death is being treated as a suspicious.
Detective Inspector Justine Jenkins, from the Bedfordshire, Cambridgeshire and Hertfordshire Major Crime Unit, said: “We have arrested a fifth person following our investigation into the death of a woman in Luton.
"We are exploring all possible options as to how the injury occurred.
"If anyone has any information that you feel could assist us, please do get in touch.”
Anyone with any information should call 101 or use our online reporting tool quoting Operation Network.
You can also contact Crimestoppers, anonymously, on 0800 555111.
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